Assistant Scientist- Downstream Job at Integrated Resources, Inc ( IRI ), Cambridge, MA

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  • Integrated Resources, Inc ( IRI )
  • Cambridge, MA

Job Description

Overview

The successful candidate will be a part of the Process Chemistry group, responsible for the process development and in-house non-GMP manufacture of modified oligonucleoProducts and siRNAs.

Summary of Key Responsibilities

  • Support non-GMP oligonucleoProduct production on a tight timeline
  • Support purification method development, optimization, and scale-up
  • Execute non-GMP oligonucleoProduct purifications
  • Execute downstream processing of purified material
  • Execute in-process analytical tests
  • Participate in creating and reviewing SOPs and batch records
  • Support campaign activities across other unit operations as-needed

Qualifications

  • BS in Chemistry with 1-3 years lab experience, preferably in an industrial setting.
  • Basic understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC-MS etc.). Related hands-on experience is preferred. Knowledge of oligonucleoProduct manufacture process including phosphoramidite chemistry, chromatography, ultrafiltration etc. is a plus.
  • Experience in record-keeping and excellent laboratory documentation practice, are required. Strong commitment to high laboratory and scientific standard; ability to maintain a safe, clean, and orderly laboratory work environment; assist in routine lab and equipment maintenance.
  • Good communication skill is a must for this position. The successful candidate must be a responsible and proactive individual who is able to work as a team player in a highly dynamic environment with aggressive timelines.

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